Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection
Identifieur interne : 000E76 ( Main/Exploration ); précédent : 000E75; suivant : 000E77Altered Lipid Metabolism in Recovered SARS Patients Twelve Years after Infection
Auteurs : Qi Wu [République populaire de Chine] ; Lina Zhou [République populaire de Chine] ; Xin Sun [République populaire de Chine] ; Zhongfang Yan [République populaire de Chine] ; Chunxiu Hu [République populaire de Chine] ; Junping Wu [République populaire de Chine] ; Long Xu [République populaire de Chine] ; Xue Li [République populaire de Chine] ; Huiling Liu [République populaire de Chine] ; Peiyuan Yin [République populaire de Chine] ; Kuan Li [République populaire de Chine] ; Jieyu Zhao [République populaire de Chine] ; Yanli Li [République populaire de Chine] ; Xiaolin Wang [République populaire de Chine] ; Yu Li [République populaire de Chine] ; Qiuyang Zhang [République populaire de Chine] ; Guowang Xu [République populaire de Chine] ; Huaiyong Chen [République populaire de Chine]Source :
- Scientific Reports [ 2045-2322 ] ; 2017.
Descripteurs français
- KwdFr :
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Lipides (sang), Mâle, Métabolisme des lipides (), Métabolome, Métabolomique (), Stéroïdes (pharmacologie), Stéroïdes (usage thérapeutique), Surveillance de la santé publique, Syndrome respiratoire aigu sévère (métabolisme), Syndrome respiratoire aigu sévère (virologie), Syndrome respiratoire aigu sévère (épidémiologie), Virus du SRAS, Voies et réseaux métaboliques, Études de suivi.
- MESH :
- métabolisme : Syndrome respiratoire aigu sévère.
- pharmacologie : Stéroïdes.
- sang : Lipides.
- usage thérapeutique : Stéroïdes.
- virologie : Syndrome respiratoire aigu sévère.
- épidémiologie : Syndrome respiratoire aigu sévère.
- Adulte, Adulte d'âge moyen, Facteurs de risque, Femelle, Humains, Mâle, Métabolisme des lipides, Métabolome, Métabolomique, Surveillance de la santé publique, Virus du SRAS, Voies et réseaux métaboliques, Études de suivi.
English descriptors
- KwdEn :
- Adult, Female, Follow-Up Studies, Humans, Lipid Metabolism (drug effects), Lipids (blood), Male, Metabolic Networks and Pathways, Metabolome, Metabolomics (methods), Middle Aged, Public Health Surveillance, Risk Factors, SARS Virus, Severe Acute Respiratory Syndrome (epidemiology), Severe Acute Respiratory Syndrome (metabolism), Severe Acute Respiratory Syndrome (virology), Steroids (pharmacology), Steroids (therapeutic use).
- MESH :
- chemical , blood : Lipids.
- drug effects : Lipid Metabolism.
- epidemiology : Severe Acute Respiratory Syndrome.
- metabolism : Severe Acute Respiratory Syndrome.
- methods : Metabolomics.
- chemical , pharmacology : Steroids.
- chemical , therapeutic use : Steroids.
- virology : Severe Acute Respiratory Syndrome.
- Adult, Female, Follow-Up Studies, Humans, Male, Metabolic Networks and Pathways, Metabolome, Middle Aged, Public Health Surveillance, Risk Factors, SARS Virus.
Abstract
Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments.
Url:
DOI: 10.1038/s41598-017-09536-z
PubMed: 28831119
PubMed Central: 5567209
Affiliations:
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institution-id-type="ISNI">0000 0000 9792 1228</institution-id><institution-id institution-id-type="GRID">grid.265021.2</institution-id><institution>Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine,</institution><institution>Tianjin Institute of Respiratory Diseases, Haihe Clinical College of Tianjin Medical University,</institution></institution-wrap>Tianjin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tianjin</wicri:regionArea></affiliation></author><author><name sortKey="Zhou, Lina" sort="Zhou, Lina" uniqKey="Zhou L" first="Lina" last="Zhou">Lina Zhou</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1793 300X</institution-id><institution-id institution-id-type="GRID">grid.423905.9</institution-id><institution>CAS Key Laboratory of Separation Sciences for Analytical Chemistry,</institution><institution>Dalian Institute of Chemical Physics, Chinese Academy of Sciences,</institution></institution-wrap>Dalian, 116023 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Sun, Xin" sort="Sun, Xin" uniqKey="Sun X" first="Xin" last="Sun">Xin Sun</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.417026.6</institution-id><institution>Department of Respiratory Medicine,</institution><institution>Tianjin Haihe Hospital,</institution></institution-wrap>Tianjin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tianjin</wicri:regionArea></affiliation></author><author><name sortKey="Yan, Zhongfang" sort="Yan, Zhongfang" uniqKey="Yan Z" first="Zhongfang" last="Yan">Zhongfang Yan</name><affiliation wicri:level="1"><nlm:aff id="Aff4"><institution-wrap><institution-id institution-id-type="GRID">grid.417026.6</institution-id><institution>Department of Nutrition,</institution><institution>Tianjin Haihe Hospital,</institution></institution-wrap>Tianjin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tianjin</wicri:regionArea></affiliation></author><author><name sortKey="Hu, Chunxiu" sort="Hu, Chunxiu" uniqKey="Hu C" first="Chunxiu" last="Hu">Chunxiu Hu</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1793 300X</institution-id><institution-id institution-id-type="GRID">grid.423905.9</institution-id><institution>CAS Key Laboratory of Separation Sciences for Analytical Chemistry,</institution><institution>Dalian Institute of Chemical Physics, Chinese Academy of Sciences,</institution></institution-wrap>Dalian, 116023 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Wu, Junping" sort="Wu, Junping" uniqKey="Wu J" first="Junping" last="Wu">Junping Wu</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.417026.6</institution-id><institution>Department of Respiratory Medicine,</institution><institution>Tianjin Haihe Hospital,</institution></institution-wrap>Tianjin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tianjin</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Long" sort="Xu, Long" uniqKey="Xu L" first="Long" last="Xu">Long Xu</name><affiliation wicri:level="1"><nlm:aff id="Aff3"><institution-wrap><institution-id institution-id-type="GRID">grid.417026.6</institution-id><institution>Department of Respiratory Medicine,</institution><institution>Tianjin Haihe Hospital,</institution></institution-wrap>Tianjin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tianjin</wicri:regionArea></affiliation></author><author><name sortKey="Li, Xue" sort="Li, Xue" uniqKey="Li X" first="Xue" last="Li">Xue Li</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.417026.6</institution-id><institution>Department of Basic Medicine,</institution><institution>Tianjin Haihe Hospital,</institution></institution-wrap>Tianjin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tianjin</wicri:regionArea></affiliation></author><author><name sortKey="Liu, Huiling" sort="Liu, Huiling" uniqKey="Liu H" first="Huiling" last="Liu">Huiling Liu</name><affiliation wicri:level="1"><nlm:aff id="Aff6"><institution-wrap><institution-id institution-id-type="GRID">grid.417026.6</institution-id><institution>Department of Gastroenterology,</institution><institution>Tianjin Haihe Hospital,</institution></institution-wrap>Tianjin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tianjin</wicri:regionArea></affiliation></author><author><name sortKey="Yin, Peiyuan" sort="Yin, Peiyuan" uniqKey="Yin P" first="Peiyuan" last="Yin">Peiyuan Yin</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1793 300X</institution-id><institution-id institution-id-type="GRID">grid.423905.9</institution-id><institution>CAS Key Laboratory of Separation Sciences for Analytical Chemistry,</institution><institution>Dalian Institute of Chemical Physics, Chinese Academy of Sciences,</institution></institution-wrap>Dalian, 116023 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Li, Kuan" sort="Li, Kuan" uniqKey="Li K" first="Kuan" last="Li">Kuan Li</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.417026.6</institution-id><institution>Department of Basic Medicine,</institution><institution>Tianjin Haihe Hospital,</institution></institution-wrap>Tianjin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tianjin</wicri:regionArea></affiliation></author><author><name sortKey="Zhao, Jieyu" sort="Zhao, Jieyu" uniqKey="Zhao J" first="Jieyu" last="Zhao">Jieyu Zhao</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1793 300X</institution-id><institution-id institution-id-type="GRID">grid.423905.9</institution-id><institution>CAS Key Laboratory of Separation Sciences for Analytical Chemistry,</institution><institution>Dalian Institute of Chemical Physics, Chinese Academy of Sciences,</institution></institution-wrap>Dalian, 116023 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Li, Yanli" sort="Li, Yanli" uniqKey="Li Y" first="Yanli" last="Li">Yanli Li</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1793 300X</institution-id><institution-id institution-id-type="GRID">grid.423905.9</institution-id><institution>CAS Key Laboratory of Separation Sciences for Analytical Chemistry,</institution><institution>Dalian Institute of Chemical Physics, Chinese Academy of Sciences,</institution></institution-wrap>Dalian, 116023 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Wang, Xiaolin" sort="Wang, Xiaolin" uniqKey="Wang X" first="Xiaolin" last="Wang">Xiaolin Wang</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1793 300X</institution-id><institution-id institution-id-type="GRID">grid.423905.9</institution-id><institution>CAS Key Laboratory of Separation Sciences for Analytical Chemistry,</institution><institution>Dalian Institute of Chemical Physics, Chinese Academy of Sciences,</institution></institution-wrap>Dalian, 116023 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Li, Yu" sort="Li, Yu" uniqKey="Li Y" first="Yu" last="Li">Yu Li</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.417026.6</institution-id><institution>Department of Basic Medicine,</institution><institution>Tianjin Haihe Hospital,</institution></institution-wrap>Tianjin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tianjin</wicri:regionArea></affiliation></author><author><name sortKey="Zhang, Qiuyang" sort="Zhang, Qiuyang" uniqKey="Zhang Q" first="Qiuyang" last="Zhang">Qiuyang Zhang</name><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.417026.6</institution-id><institution>Department of Basic Medicine,</institution><institution>Tianjin Haihe Hospital,</institution></institution-wrap>Tianjin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tianjin</wicri:regionArea></affiliation></author><author><name sortKey="Xu, Guowang" sort="Xu, Guowang" uniqKey="Xu G" first="Guowang" last="Xu">Guowang Xu</name><affiliation wicri:level="1"><nlm:aff id="Aff2"><institution-wrap><institution-id institution-id-type="ISNI">0000 0004 1793 300X</institution-id><institution-id institution-id-type="GRID">grid.423905.9</institution-id><institution>CAS Key Laboratory of Separation Sciences for Analytical Chemistry,</institution><institution>Dalian Institute of Chemical Physics, Chinese Academy of Sciences,</institution></institution-wrap>Dalian, 116023 China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Dalian</wicri:regionArea></affiliation></author><author><name sortKey="Chen, Huaiyong" sort="Chen, Huaiyong" uniqKey="Chen H" first="Huaiyong" last="Chen">Huaiyong Chen</name><affiliation wicri:level="1"><nlm:aff id="Aff1"><institution-wrap><institution-id institution-id-type="ISNI">0000 0000 9792 1228</institution-id><institution-id institution-id-type="GRID">grid.265021.2</institution-id><institution>Key Research Laboratory for Infectious Disease Prevention for State Administration of Traditional Chinese Medicine,</institution><institution>Tianjin Institute of Respiratory Diseases, Haihe Clinical College of Tianjin Medical University,</institution></institution-wrap>Tianjin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tianjin</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="Aff5"><institution-wrap><institution-id institution-id-type="GRID">grid.417026.6</institution-id><institution>Department of Basic Medicine,</institution><institution>Tianjin Haihe Hospital,</institution></institution-wrap>Tianjin, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Tianjin</wicri:regionArea></affiliation></author></analytic><series><title level="j">Scientific Reports</title><idno type="eISSN">2045-2322</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Lipid Metabolism (drug effects)</term><term>Lipids (blood)</term><term>Male</term><term>Metabolic Networks and Pathways</term><term>Metabolome</term><term>Metabolomics (methods)</term><term>Middle Aged</term><term>Public Health Surveillance</term><term>Risk Factors</term><term>SARS Virus</term><term>Severe Acute Respiratory Syndrome (epidemiology)</term><term>Severe Acute Respiratory Syndrome (metabolism)</term><term>Severe Acute Respiratory Syndrome (virology)</term><term>Steroids (pharmacology)</term><term>Steroids (therapeutic use)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Lipides (sang)</term><term>Mâle</term><term>Métabolisme des lipides ()</term><term>Métabolome</term><term>Métabolomique ()</term><term>Stéroïdes (pharmacologie)</term><term>Stéroïdes (usage thérapeutique)</term><term>Surveillance de la santé publique</term><term>Syndrome respiratoire aigu sévère (métabolisme)</term><term>Syndrome respiratoire aigu sévère (virologie)</term><term>Syndrome respiratoire aigu sévère (épidémiologie)</term><term>Virus du SRAS</term><term>Voies et réseaux métaboliques</term><term>Études de suivi</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Lipids</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Lipid Metabolism</term></keywords><keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Metabolomics</term></keywords><keywords scheme="MESH" qualifier="métabolisme" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Stéroïdes</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Steroids</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Lipides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Steroids</term></keywords><keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Stéroïdes</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Severe Acute Respiratory Syndrome</term></keywords><keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Syndrome respiratoire aigu sévère</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Female</term><term>Follow-Up Studies</term><term>Humans</term><term>Male</term><term>Metabolic Networks and Pathways</term><term>Metabolome</term><term>Middle Aged</term><term>Public Health Surveillance</term><term>Risk Factors</term><term>SARS Virus</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adulte</term><term>Adulte d'âge moyen</term><term>Facteurs de risque</term><term>Femelle</term><term>Humains</term><term>Mâle</term><term>Métabolisme des lipides</term><term>Métabolome</term><term>Métabolomique</term><term>Surveillance de la santé publique</term><term>Virus du SRAS</term><term>Voies et réseaux métaboliques</term><term>Études de suivi</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p id="Par1">Severe acute respiratory syndrome-coronavirus (SARS-CoV) and SARS-like coronavirus are a potential threat to global health. However, reviews of the long-term effects of clinical treatments in SARS patients are lacking. Here a total of 25 recovered SARS patients were recruited 12 years after infection. Clinical questionnaire responses and examination findings indicated that the patients had experienced various diseases, including lung susceptibility to infections, tumors, cardiovascular disorders, and abnormal glucose metabolism. As compared to healthy controls, metabolomic analyses identified significant differences in the serum metabolomes of SARS survivors. The most significant metabolic disruptions were the comprehensive increase of phosphatidylinositol and lysophospha tidylinositol levels in recovered SARS patients, which coincided with the effect of methylprednisolone administration investigated further in the steroid treated non-SARS patients with severe pneumonia. These results suggested that high-dose pulses of methylprednisolone might cause long-term systemic damage associated with serum metabolic alterations. The present study provided information for an improved understanding of coronavirus-associated pathologies, which might permit further optimization of clinical treatments.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Van Der Hoek, L" uniqKey="Van Der Hoek L">L van der Hoek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Woo, Pc" uniqKey="Woo P">PC Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berry, M" uniqKey="Berry M">M Berry</name></author><author><name sortKey="Gamieldien, J" uniqKey="Gamieldien J">J Gamieldien</name></author><author><name sortKey="Fielding, Bc" uniqKey="Fielding B">BC Fielding</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Menachery, Vd" uniqKey="Menachery V">VD Menachery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ge, Xy" uniqKey="Ge X">XY Ge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tsang, Kw" uniqKey="Tsang K">KW Tsang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chen, Xp" uniqKey="Chen X">XP Chen</name></author><author><name sortKey="Cao, Y" uniqKey="Cao Y">Y Cao</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sainz, B" uniqKey="Sainz B">B Sainz</name></author><author><name sortKey="Mossel, Ec" uniqKey="Mossel E">EC Mossel</name></author><author><name sortKey="Peters, Cj" uniqKey="Peters C">CJ Peters</name></author><author><name sortKey="Garry, Rf" uniqKey="Garry R">RF Garry</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheng, Y" uniqKey="Cheng Y">Y Cheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jia, Wd" uniqKey="Jia W">WD Jia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yam, Ly" uniqKey="Yam L">LY Yam</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Xu, Yd" uniqKey="Xu Y">YD Xu</name></author><author><name sortKey="Jiang, M" uniqKey="Jiang M">M Jiang</name></author><author><name sortKey="Chen, Rc" uniqKey="Chen R">RC Chen</name></author><author><name sortKey="Fang, Jq" uniqKey="Fang J">JQ Fang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lam, Cw" uniqKey="Lam C">CW Lam</name></author><author><name sortKey="Chan, Mh" uniqKey="Chan M">MH Chan</name></author><author><name sortKey="Wong, Ck" uniqKey="Wong C">CK Wong</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chan, Mh" uniqKey="Chan M">MH Chan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Griffith, Jf" uniqKey="Griffith J">JF Griffith</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ruiz Arguello, Mb" uniqKey="Ruiz Arguello M">MB Ruiz-Arguello</name></author><author><name sortKey="Goni, Fm" uniqKey="Goni F">FM Goni</name></author><author><name sortKey="Pereira, Fb" uniqKey="Pereira F">FB Pereira</name></author><author><name sortKey="Nieva, Jl" uniqKey="Nieva J">JL Nieva</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Johnson, Ka" uniqKey="Johnson K">KA Johnson</name></author><author><name sortKey="Taghon, Gj" uniqKey="Taghon G">GJ Taghon</name></author><author><name sortKey="Scott, Jl" uniqKey="Scott J">JL Scott</name></author><author><name sortKey="Stahelin, Rv" uniqKey="Stahelin R">RV Stahelin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Li, L" uniqKey="Li L">L Li</name></author><author><name sortKey="Sun, X" uniqKey="Sun X">X Sun</name></author><author><name sortKey="Wu, Q" uniqKey="Wu Q">Q Wu</name></author><author><name sortKey="Xing, Z" uniqKey="Xing Z">Z Xing</name></author><author><name sortKey="Yu, H" uniqKey="Yu H">H Yu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, N" uniqKey="Yang N">N Yang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Numata, M" uniqKey="Numata M">M Numata</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Imbernon, M" uniqKey="Imbernon M">M Imbernon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Metz, Sa" uniqKey="Metz S">SA Metz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Romero Zerbo, Sy" uniqKey="Romero Zerbo S">SY Romero-Zerbo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Overgaard, Aj" uniqKey="Overgaard A">AJ Overgaard</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lauckner, Je" uniqKey="Lauckner J">JE Lauckner</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schicho, R" uniqKey="Schicho R">R Schicho</name></author><author><name sortKey="Storr, M" uniqKey="Storr M">M Storr</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ford, La" uniqKey="Ford L">LA Ford</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wu, R" uniqKey="Wu R">R Wu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Rohn, H" uniqKey="Rohn H">H Rohn</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>République populaire de Chine</li></country></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Wu, Qi" sort="Wu, Qi" uniqKey="Wu Q" first="Qi" last="Wu">Qi Wu</name></noRegion><name sortKey="Chen, Huaiyong" sort="Chen, Huaiyong" uniqKey="Chen H" first="Huaiyong" last="Chen">Huaiyong Chen</name><name sortKey="Chen, Huaiyong" sort="Chen, Huaiyong" uniqKey="Chen H" first="Huaiyong" last="Chen">Huaiyong Chen</name><name sortKey="Hu, Chunxiu" sort="Hu, Chunxiu" uniqKey="Hu C" first="Chunxiu" last="Hu">Chunxiu Hu</name><name sortKey="Li, Kuan" sort="Li, Kuan" uniqKey="Li K" first="Kuan" last="Li">Kuan Li</name><name sortKey="Li, Xue" sort="Li, Xue" uniqKey="Li X" first="Xue" last="Li">Xue Li</name><name sortKey="Li, Yanli" sort="Li, Yanli" uniqKey="Li Y" first="Yanli" last="Li">Yanli Li</name><name sortKey="Li, Yu" sort="Li, Yu" uniqKey="Li Y" first="Yu" last="Li">Yu Li</name><name sortKey="Liu, Huiling" sort="Liu, Huiling" uniqKey="Liu H" first="Huiling" last="Liu">Huiling Liu</name><name sortKey="Sun, Xin" sort="Sun, Xin" uniqKey="Sun X" first="Xin" last="Sun">Xin Sun</name><name sortKey="Wang, Xiaolin" sort="Wang, Xiaolin" uniqKey="Wang X" first="Xiaolin" last="Wang">Xiaolin Wang</name><name sortKey="Wu, Junping" sort="Wu, Junping" uniqKey="Wu J" first="Junping" last="Wu">Junping Wu</name><name sortKey="Xu, Guowang" sort="Xu, Guowang" uniqKey="Xu G" first="Guowang" last="Xu">Guowang Xu</name><name sortKey="Xu, Long" sort="Xu, Long" uniqKey="Xu L" first="Long" last="Xu">Long Xu</name><name sortKey="Yan, Zhongfang" sort="Yan, Zhongfang" uniqKey="Yan Z" first="Zhongfang" last="Yan">Zhongfang Yan</name><name sortKey="Yin, Peiyuan" sort="Yin, Peiyuan" uniqKey="Yin P" first="Peiyuan" last="Yin">Peiyuan Yin</name><name sortKey="Zhang, Qiuyang" sort="Zhang, Qiuyang" uniqKey="Zhang Q" first="Qiuyang" last="Zhang">Qiuyang Zhang</name><name sortKey="Zhao, Jieyu" sort="Zhao, Jieyu" uniqKey="Zhao J" first="Jieyu" last="Zhao">Jieyu Zhao</name><name sortKey="Zhou, Lina" sort="Zhou, Lina" uniqKey="Zhou L" first="Lina" last="Zhou">Lina Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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